• Marjolein van Heugten and Lonneke van Onzenoort-Bokken.
• From the Department of Paediatrics, Máxima Medical Centre, Veldhoven, the Netherlands.
• Pediatr Emerg Care. 2021 Dec 1; 37 (12): e866e867e866-e867.

ObjectiveWe aimed to describe a case of prematurely born infant with accidental sildenafil overdose.MethodsThis was a retrospective case report followed with chart and literature review.Main FindingsA prematurely born infant with moderate bronchopulmonary dysplasia, corrected congenital heart disease, and pulmonary hypertension presented with an accidental sildenafil overdose. Despite the relatively high dose in this medically frail infant and the long elimination half-life of sildenafil in infants, the symptoms of sildenafil overdose in our patient were only mild. After a short and uneventful period of observation in the hospital, the patient was discharged home.ConclusionsSildenafil overdose can cause serious symptoms such as hypotension. However, in our case, the sildenafil overdose was well tolerated, even by a young patient with underlying heart and lung disease. We show that choices in the management of sildenafil intoxication can be made based on the knowledge of sildenafil pharmacokinetics in young children.Copyright © 2021 Wolters Kluwer Health, Inc. All rights reserved.

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