• Eur. J. Pediatr. · Nov 1994

    Clinical Trial

    Adenosine-tri-phosphate treatment for supraventricular tachycardia in infants.

    • D De Wolf, G Rondia, H Verhaaren, and D Matthys.
    • A.Z.-Kinderen V.U.B., Brussels, Belgium.
    • Eur. J. Pediatr. 1994 Nov 1; 153 (11): 793-6.

    AbstractAdenosine is an endogenous nucleoside acting on coronary perfusion and myocardial conduction. Although the anti-arrhythmic effects of adenosine have been known for decades, interest in the use of adenosine or adenosine-triphosphate (ATP) (a precursor of adenosine) in termination of supraventricular tachycardia (SVT) has been renewed. We studied the use of striadyne (ATP and a mixture of other nucleosides including adenosine) in 22 infants younger than 6 months in order to evaluate efficiency and safety of the drug in this particular age group. Striadyne stopped SVT in 17 cases and was diagnostic in another 4 cases. Ten out of 17 successfully converted infants showed one or more reinitiations of SVT, which were easily controlled. The results support the efficiency of ATP for the termination of re-entry types of tachycardia, as well as its diagnostic value and its lack of serious side-effects.

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