• Brian Cowie, Roman Kluger, Steffen Rex, and Carlo Missant.
• Department of Anesthesia, St. Vincent's Hospital, Melbourne, Australia; Department of Anesthesiology, University Hospitals Leuven, Leuven, Belgium, Australia.
• Ann Card Anaesth. 2015 Jul 1; 18 (3): 312-6.

BackgroundThe pulmonary artery catheter (PAC) has historically been used to measure cardiac filling pressures of which pulmonary capillary wedge pressure (PCWP) has been used as a surrogate of left atrial pressure (LAP) and left ventricular end-diastolic pressure. Increasingly, the use of the PAC has been questioned in the perioperative period with multiple large studies unable to clearly demonstrate benefit in any group of patients, resulting in a declining use in the perioperative period. Alternative methods for the noninvasive estimation of left-sided filling pressures are required. Echocardiography has been used to provide noninvasive estimation of PCWP and LAP, based on evaluating mitral inflow velocity with the E and A waves and looking at movement of the mitral annulus with tissue Doppler (e').AimThe aim of our study was to assess the relationship between PCWP and E/e' in cardiac surgical patients with transesophageal echocardiography (TOE).DesignA prospective observational study.SettingCardiac surgical patients in a single quaternary referral university teaching hospital.MethodsThe ratio of mitral inflow velocity (E wave) to mitral annular tissue velocity (e') (the E/e' ratio) and PCWP of 91 patients undergoing general anesthesia and cardiac surgery were simultaneously recorded, with the use of TOE and a PAC.ResultsThe correlation between E/e' and PCWP was modest with a Spearman rank correlation coefficient of 0.29 (P = 0.005). The area under the receiver operating characteristic curve for using E/e' to predict elevated PCWP (≥18 mmHg) was 0.6825 (95% confidence interval: 0.57-0.80), indicating some predictive utility. The optimum threshold value of E/e' was 10 which had 71% sensitivity and 60% specificity to predict a PCWP ≥18 mmHg.ConclusionsNoninvasive measurements of E/e' in general cardiac surgical patients have only a modest correlation and does not reliably estimate PCWP.

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