• Rafael San-Juan, Patricia Barbero, Mario Fernández-Ruiz, Francisco López-Medrano, Manuel Lizasoáin, Pilar Hernández-Jiménez, José Tiago Silva, María Ruiz-Ruigómez, Laura Corbella, Isabel Rodríguez-Goncer, María Dolores Folgueira, Antonio Lalueza, Emma Batllori, Inma Mejía, Laura Forcén, Carlos Lumbreras, Antonio García-Burguillo, Alberto Galindo, and José María Aguado.
• Unit of Infectious Diseases, Hospital Universitario "12 de Octubre", Instituto de Investigación Sanitaria Hospital "12 de Octubre" (imas12), Complutense University, 2ª planta, bloque D. Avda. de Córdoba, s/n. Madrid, Spain.
• EClinicalMedicine. 2020 Jun 1; 23: 100407.

BackgroundInformation regarding the incidence and characteristics of COVID-19 pneumonia amongst pregnant women is scarce.MethodsSingle-centre experience with 32 pregnant women diagnosed with COVID-19 between March 5 to April 5, 2020 at Madrid, Spain.FindingsCOVID-19 pneumonia was diagnosed in 61·5% (32/52) women. Only 18·7% (6/32) had some underlying condition (mostly asthma). Supplemental oxygen therapy was required in 18 patients (56·3%), with high-flow requirements in six (18·7%). Eight patients (25·0%) fulfilled the criteria for acute distress respiratory syndrome. Invasive mechanical ventilation was required in two patients (6·2%). Tocilizumab was administered in five patients (15·6%). Delivery was precipitated due to COVID-19 in three women (9·4%). All the newborns had a favourable outcome, with no cases of neonatal SARS-CoV-2 transmission. Severe cases of pneumonia requiring supplemental oxygen were more likely to exhibit bilateral alveolar or interstitial infiltrates on chest X-ray (55·6% vs. 0·0%; P-value = 0·003) and serum C-reactive protein (CRP) levels >10 mg/dL (33·0% vs. 0·0%; P-value = 0·05) at admission than those with no oxygen requirements.InterpretationPregnant women with COVID-19 have a high risk of developing pneumonia, with a severe course in more than half of cases. The presence of bilateral kung infiltrates and elevated serum CRP at admission may identify women at-risk of severe COVID-19 pneumonia.FundingInstituto de Salud Carlos III (COV20/00,181), Spanish Ministry of Science and Innovation.© 2020 The Author(s).

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