• The Journal of infection · Jan 2015

    Mitochondrial DNA haplogroups are associated with severe sepsis and mortality in patients who underwent major surgery.

    • Maria Angeles Jiménez-Sousa, Eduardo Tamayo, María Guzmán-Fulgencio, María Heredia, Amanda Fernández-Rodríguez, Esther Gómez, Raquel Almansa, José I Gómez-Herreras, Mónica García-Álvarez, Sandra Gutiérrez-Junco, Jesús F Bermejo-Martin, Salvador Resino, and Spanish Sepsis Group (SpSG).
    • Unidad de Infección Viral e Inmunidad, Centro Nacional de Microbiología, Instituto de Salud Carlos III, Majadahonda, Spain. Electronic address: majimenezsousa@yahoo.es.
    • J. Infect. 2015 Jan 1; 70 (1): 20-9.

    ObjectiveTo analyse whether mitochondrial DNA (mtDNA) haplogroups are associated with severe sepsis and mortality after major surgery.MethodsWe performed a case-control study on 240 cardiac or abdominal surgery patients developing severe sepsis (Case-group) and 267 cardiac or abdominal surgery patients without severe sepsis and with systemic inflammatory response syndrome (SIRS, Control-group). Furthermore, a longitudinal substudy was performed for analysing the survival in septic patients. Only European white patients within the N macro-cluster were included.ResultsCase-group underwent cardiac surgery had lower frequencies of cluster HV (p = 0.005) and haplogroup H (p = 0.005) and higher frequencies of cluster JT (p = 0.028) than Control-group; but no significant differences were found for abdominal surgery. Besides, both cluster HV and haplogroup H were associated with decreased odds of severe sepsis (adjusted odds ratio (aOR) = 0.45 (95%CI = 0.25; 0.82); p = 0.009 and aOR = 0.48 (95%CI = 0.26; 0.87); p = 0.015, respectively) among patients underwent cardiac surgery. In Case-group, 45.4% (109/240) patients died with a survival median of 39 (95%CI = 31.4; 46.62) days. When the clusters were examined, 41% (55/134) patients within cluster HV died versus 71.4% (10/14) patients within cluster IWX (p = 0.018). Additionally, patients within cluster IWX had an increased risk of death (adjusted hazard ratio (aHR) = 2.22; (95%CI = 1.14; 4.34); p = 0.019).ConclusionsEuropean mitochondrial haplogroups might be related to the onset of severe sepsis in patients who underwent major cardiac surgery, but not in patients underwent major abdominal surgery. Besides, mtDNA haplogroups could have influence on mortality in septic patients.Copyright © 2014 The British Infection Association. Published by Elsevier Ltd. All rights reserved.

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