• Michele Umbrello, Nicola Brena, Ruggero Vercelli, Riccardo Alessandro Foa, Marco Femia, Umberto Rossi, Gian Marco Podda, Francesca Cortellaro, and Stefano Muttini.
• SC Anestesia e Rianimazione II, Ospedale San Carlo Borromeo, ASST Santi Paolo e Carlo - Polo Universitario, Milano, Italy. Electronic address: michele.umbrello@asst-santipaolocarlo.it.
• J Crit Care. 2021 Oct 1; 65: 727572-75.

AbstractSeveral cases of deep venous thrombosis in people who had recently received Vaxzevria (previously known as COVID-19 Vaccine AstraZeneca) have recently been reported, mainly presenting as cerebral vein/cerebral venous sinus thrombosis. This syndrome has been termed "vaccine-induced immune thrombotic thrombocytopenia (VITT)". Acute spleno-porto-mesenteric vein thrombosis is an uncommon but serious condition with potential sequelae, such as small-bowel gangrene and end-stage liver failure. We describe a case of concomitant thrombosis of portal, superior mesenteric and splenic veins in a young female patient with no other risk factors who received Vaxzevria (previously ChAdOx1 nCoV-19 vaccine, AstraZeneca) 17 days before. The diagnostic workup and the successful endovascular treatment and systemic anticoagulation management is reported.Copyright © 2021 Elsevier Inc. All rights reserved.

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