• Zilong Shao, Zhibin Wang, Liwei Shao, and Xiang Jin.
• Department of Emergency Medicine, Taikang Tongji (Wuhan) Hospital.
• Medicine (Baltimore). 2021 Jun 4; 100 (22): e25889e25889.

BackgroundWith the attention paid to the heritability of breast cancer, the search for the genetic susceptibility gene of breast cancer has become a hot spot. At present, a number of studies have explored the relationship between rs13347 polymorphism of cluster of differentiation 44 (CD44) gene and breast cancer, but the research conclusions are inconsistent. Therefore, we will use this meta-analysis to explore the role of this gene polymorphism in breast cancer susceptibility.MethodsThe search time is set from the establishment of the database in March 2021 in this study. The search database include China National Knowledge Infrastructure, Wanfang, VIP Information Chinese Journal Service Platform, and China Biology Medicine disc, PubMed, EMBASE, Web of Science and the Cochrane Library. The subjects are observational studies on the relationship between rs13347 polymorphism of CD44 gene and breast cancer (including case-control study, cross-sectional study and a cohort study). The language is limited to English and Chinese. The data of the included study are extracted and the literature quality is evaluated by two researchers independently. The data are statistically analyzed by Stata 16.0 software.ResultsBased on the existing studies, this study will systematically evaluate the relationship between CD44 gene rs13347 polymorphism and breast cancer.ConclusionThis study will provide evidence-based medical evidence to clarify the role of CD44 gene polymorphism in breast cancer, and provide help for the early detection and preventive intervention of breast cancer.Ethics And DisseminationPrivate information from individuals will not be published. This systematic review also does not involve endangering participant rights. Ethical approval will not be required. The results may be published in a peer-reviewed journal or disseminated at relevant conferences.Osf Registration NumberDOI 10.17605/OSF.IO/WBC7F.Copyright © 2021 the Author(s). Published by Wolters Kluwer Health, Inc.

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