• Huan Wang, Qiulei Jia, Jingjing Shi, and Yuanhui Hu.
• Department of Cardiology, Guang'anmen Hospital, China Academy of Chinese Medical Sciences.
• Medicine (Baltimore). 2021 Jun 4; 100 (22): e26180e26180.

BackgroundHeart failure (HF) is one of the common and critical disease, and often accompanied by increased level of serum bilirubin, but the role of an indicator of bilirubin to monitor the prognosis of patients with heart failure is still unclear, so we implemented the study to systematically evaluate the predictive value of bilirubin in HF.MethodsA comprehensive search and systematic review will be conducted on electronic databases such as Medline, Cochrane Library, Embase, Web of Science, Cochrane Clinical Trials Database of study on the relationship between bilirubin and prognosis of HF patients. Review Manager software (version 5.3.5) and STATA 14 software (version 14.0) will be used for data analysis and synthesis.ResultsThe results will systematically and comprehensively reveal the evidence on the predictive value of bilirubin in HF.ConclusionThe study will display the effect of bilirubin level on the prognosis of patients with heart failure, and help clinicians to pay more attention to the level of bilirubin in patients with HF, and can take certain treatment measures as earlier as possible.Inplasy Registration NumberINPLASY202140116.Copyright © 2021 the Author(s). Published by Wolters Kluwer Health, Inc.

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