• Hua Jiang, Yizhou Jiang, Zhenyin Liu, Yiqun Guo, and Jing Zhang.
• Department of Interventional Radiology and Vascular Anomalies, The Affiliated Hospital of Guangzhou Medical University, Guangzhou Women and Children's Medical Center.
• Medicine (Baltimore). 2021 May 14; 100 (19): e25870.

IntroductionIntra-arterial chemotherapy (IAC) has been used successfully for unilateral and bilateral eye disease with advanced or less advanced intraocular disease and of children as young as 3 months of age. In this study, we expanded the use of IAC to eyes of two infants with very low birthweight (birth weight of 1000-1500 g) and retinoblastoma.Patient ConcernsThe ophthalmologists refused to give patients intravenous chemotherapy (IVC), considering the risk of IVC because of the low body weight.DiagnosisTwo patients were diagnosed unilateral eye retinoblastoma at 31 days old and 27 days old respectively when newborn fundus screening.InterventionsChemotherapeutic agents were injected into the ophthalmic artery during the four IAC session. The two patients' oculars were preserved due to calcification during follow-up periods to the final IAC.OutcomesComplications included eyelid edema in the patient #1 and neutropenia in both patients. No fever, sepsis and other systemic toxic effects were observed. After two successful IAC treatment for each patient, their oculars were all preserved without serious complications.LessonsOur center for the first time reported the management of retinoblastoma in very low birthweight infants with especially challenging and we recommend this to be useful to the patient community.Copyright © 2021 the Author(s). Published by Wolters Kluwer Health, Inc.

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