• Mingfang Yang and Yu Shi.
• Beibei Traditional Chinese Medical Hospital, Chongqing, China.
• Medicine (Baltimore). 2021 May 14; 100 (19): e25896e25896.

BackgroundEarly diagnosis of cholecystolithiasis is significant for prevention of further development of situation. Ultrasound is the best choice for the diagnosis of cholecystolithiasis with a sensitivity of >95% and specificity of practically 100%. However, ultrasound is not perfect for it is not so clear sometimes. So, MRI is needed to assist the diagnosing of cholecystolithiasis. Some studies have been conducted to investigate the diagnostic value of ultrasound combined with MRI in cholecystolithiasis, however, the evidence was not enough.MethodsWe will search the following sources for the identification of trials: The Cochrane Library, PubMed, EMBASE, Chinese Biomedical Literature Database (CBM), Chinese National Knowledge Infrastructure Database (CNKI), Chinese Science and Technique Journals Database (VIP), and the Wanfang Database. The searches were limited to articles published before 1st, April, 2021, and the language were limited to Chinese and English. Statistical analyses will be conducted with Sata 14.0 software and the evaluation of the quality of the included studies will be performed by the Quality Assessment of Diagnostic Accuracy Studies (QUADAS-2).ResultsThis study will provide a rational synthesis of current evidences for MRI combined with ultrasound for cholecystolithiasis.ConclusionThe conclusion of this study will provide evidence for the diagnostic value of MRI combined with ultrasound for cholecystolithiasis.Ethics And DisseminationThis protocol will not evaluate individual patient information or affect patient rights and therefore does not require ethical approval. Results from this review will be disseminated through peer-reviewed journals and conference reports.Prospero Registration NumberINPLASY202130003.Copyright © 2021 the Author(s). Published by Wolters Kluwer Health, Inc.

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