• Renliang Li, Ping Zhang, Ziyi Hu, Ying Yi, Lisha Chen, and Hengyi Zhang.
• Jiangxi University of Traditional Chinese Medicine.
• Medicine (Baltimore). 2021 May 14; 100 (19): e25949e25949.

BackgroundHelicobacter pylori (H pylori) infection is a common health problem, which is closely related to peptic ulcers, gastric cancer, and extragastric diseases. Drugs can successfully eradicate it. However, the recurrence of H pylori often occurs after initial eradication. To confirm the global incidence of H pylori reinfection and systematically evaluate its risk factors.MethodsWe will search for the relevant literature through Chinese and English databases, with the retrieval deadline being November 2021. Databases include PubMed, Embase, Web of Science, the Cochrane Library, China National Knowledge Infrastructure, the Chongqing VIP Chinese Science and Technology Periodical Database, Wanfang Database, and China Biomedical Literature Database. Stata14.0 will be used to conduct this systematic review. The preferred reporting items for systematic reviews and meta-analysis protocols statements are followed in this protocol, and the PRISMA statement will be followed in the completed systematic review.ResultsThe results will be published in a peer-reviewed journal.ConclusionsThis systematic review will provide evidence regarding the rate of H pylori reinfection and its risk factors after successful eradication. It can guide the management of patients with H pylori infection.Copyright © 2021 the Author(s). Published by Wolters Kluwer Health, Inc.

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