• Xuewei Yin, Yi Ding, Liming Yu, Chenchen Guo, Yanyan Cui, Xixi Zhai, Yan Wang, Shumin Ding, Mingyue Shen, Zonghong Li, and Ruirong Xu.
• Shandong University of Traditional Chinese Medicine.
• Medicine (Baltimore). 2021 Jun 11; 100 (23): e26098e26098.

BackgroundAcute myeloid leukemia (AML) is the most common malignant tumor of the hematopoietic system, which seriously threatens the lives of patients. Most AML patients have acute onset, severe condition, and poor prognosis. The present study aimed to comprehensively evaluate the effectiveness and safety of chemotherapy combined with different doses of interleukin-2 (IL-2) maintenance treatments in AML by Bayesian network meta-analysis (NMA).MethodsFrom its inception until October 2021, we will search PubMed, Cochrane Library, CNKI, Embase, and other databases to comprehensively collect randomized controlled trials (RCTs) of chemotherapy combined with different doses of IL-2 maintenance therapies for AML. Two independent researchers will complete the literature screening and data extraction according to the inclusion and exclusion criteria, and then independently conduct a bias risk assessment of all the evidence. Bayesian NMA was used to evaluate all the evidence comprehensively. Use STATA16.0 and WinBUGS1.4.3 software to process and analyze all data, and classify the quality of evidence in NMA according to grading of recommendations assessment, development, and evaluation .ResultsThe study will evaluate the efficacy and safety of chemotherapy combined with different doses of IL-2 maintenance therapies for AML.ConclusionThe study will provide a basis for the efficacy and safety of chemotherapy combined with different doses of IL-2 maintenance therapies for AML. We hope that this study can provide meaningful support for clinicians and patients.Protocol Registration NumberINPLASY202140106.Ethical ApprovalSince the study is based on published or registered RCTs, ethical approval and patient informed consent are abandoned.Copyright © 2021 the Author(s). Published by Wolters Kluwer Health, Inc.

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