• Xiali Xue, Huan Tu, Zhongyi Deng, Ling Zhou, Ning Li, and Xiaokun Wang.
• Institute of Sports Medicine and Health, Chengdu Sport University.
• Medicine (Baltimore). 2021 Jun 11; 100 (23): e26254e26254.

BackgroundIn recent years, with the development of medical technology and the increase of inter-disciplinary cooperation technology, new methods in the field of artificial intelligence medicine emerge in an endless stream. Brain-computer interface (BCI), as a frontier technology of multidisciplinary integration, has been widely used in various fields. Studies have shown that BCI-assisted training can improve upper limb function in stroke patients, but its effect is still controversial and lacks evidence-based evidence, which requires further exploration and confirmation. Therefore, the main purpose of this paper is to systematically evaluate the efficacy of different BCI-assisted training on upper limb function recovery in stroke patients, to provide a reference for the application of BCI-assisted technology in stroke rehabilitation.MethodsWe will search PubMed, Web of Science, The Cochrane Library, Chinese National Knowledge Infrastructure Database, Wanfang Data, Weipu Electronics, and other databases (from the establishment to February 2021) for full text in Chinese and English. Randomized controlled trials were collected to examine the effect of BCI-assisted training on upper limb functional recovery in stroke patients. We will consider inclusion, select high-quality articles for data extraction and analysis, and summarize the intervention effect of BCI-assisted training on the upper limb function of stroke patients. Two reviewers will screen titles, abstracts, and full texts independently according to inclusion criteria; Data extraction and risk of bias assessment were performed in the included studies. We will use a hierarchy of recommended assessment, development, and assessment methods to assess the overall certainty of the evidence and report findings accordingly. Endnote X8 will be applied in selecting the study, Review Manager 5.3 will be applied in analyzing and synthesizing.ResultsThe results will provide evidence for judging whether BCI is effective and safe in improving upper limb function in patients with stroke.ConclusionOur study will provide reliable evidence for the effect of BCI technology on the improvement of upper limb function in stroke patients.Prospero Registration NumberCRD42021250378.Copyright © 2021 the Author(s). Published by Wolters Kluwer Health, Inc.

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