• Su-In Hwang, Soo-Hyun Sung, Young-Jin Yoon, and Jang-Kyung Park.
• Department of Korean Medicine Obstetrics and Gynecology, Pusan National University Korean Medicine Hospital.
• Medicine (Baltimore). 2021 Jun 11; 100 (23): e26306e26306.

BackgroundInfertility causes emotional and psychological problems, including anxiety, depression, low self-efficacy, and chronic mental stress in women. These emotional problems can negatively affect fertility treatment. Numerous studies have reported the clinical therapeutic effects of acupuncture on emotional problems; however, the efficacy and safety of acupuncture treatment for emotional problems in infertile women remain unclear. This protocol aims to evaluate the efficacy and safety of acupuncture for treating emotional problems in infertile women.MethodsWe will search the following databases from their inception to April 30, 2021: MEDLINE, EMBASE, Cochrane Library, Korean Medical Databases (KoreaMed, Korean studies Information Service System, Korean Traditional Knowledge Portal, Oriental Medicine Advanced Searching Integrated System, Research Information Sharing Service, and National Digital Science Library), and Chinese databases (CNKI and Wan Fang Database). We will include randomized controlled trials on acupuncture for emotional problems in infertile women. There will be no restrictions regarding language or publication date. The primary outcome will be assessed using an emotion-related assessment scale. The risk of bias of the included studies will be measured using the Cochrane risk of bias assessment tool. For meta-analysis, RevMan Version 5.4 software will be used to combine the relative risks for dichotomous outcomes, as well as the mean differences or standardized mean differences for continuous outcomes, with both having 95% confidence intervals.ResultsBased on current evidence, this study will assess the effectiveness and safety of acupuncture for emotional problems in infertile women.ConclusionThis study will provide evidence for evaluating the acupuncture efficacy for infertile women with emotional problems.Registration NumberINPLASY202150082.Copyright © 2021 the Author(s). Published by Wolters Kluwer Health, Inc.

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