• Panminerva medica · Mar 2017

    Review Meta Analysis

    C-Met as a potential novel prognostic marker in squamous cell carcinoma and adenocarcinoma of esophagus: evidence from a meta-analysis.

    • Jing L Ren, Hui F Wu, Wen J Wang, Gui M Hu, Bin Gu, Min Zhang, and Yu X Wang.
    • Department of Pathology, the Second Affiliated Hospital, Zhengzhou University, Zhengzhou, China - jingliren123002@126.com.
    • Panminerva Med. 2017 Mar 1; 59 (1): 97-106.

    AbstractINTRODUCTIONː The prognostic value of c-Met in patients with esophageal cancer (EC) remains inconsistent and controversial. Our study aims to clarify the correlation between c-Met overexpression and clinical outcome in EC patients. EVIDENCE ACQUISITIONː We performed a comprehensive search of EMBASE, PubMed, Web of Science, Chinese National Knowledge Infrastructure (CNKI) and Chinese Biomedical Database (CBM) (from inception to May 1, 2016) for published literature regarding the potential association between c-Met overexpression and clinical outcome in EC patients. A fixed-effects or random-effects model according to heterogeneity was applied to calculate the pooled hazard ratios (HRs) with 95% confidence intervals (CIs) for overall survival (OS), disease-free survival (DFS) and disease-specific survival (DSS). EVIDENCE SYNTHESISː Nine eligible studies totaling 1062 patients were identified in this meta-analysis. C-Met overexpression was significantly associated with shorter OS (HR: 2.04, 95% CI: 1.66-2.52, P<0.001) and DSS (HR: 3.03, 95% CI: 2.04-4.48, P<0.001) in patients with EC. However, no significant relationship between high expression of c-Met and DFS that was found (HR: 1.81, 95% CI: 0.77-4.26, P=0.176). For OS, similar associations were demonstrated in either esophageal squamous cell carcinoma (ESCC) (HR: 2.17, 95% CI: 1.62-2.90, P<0.001) or esophageal adenocarcinoma (EAC) (HR: 1.92, 95% CI: 1.42-2.59, P<0.001). Additionally, further subgroup analyses according to publication year, ethnicity, the sample size, and statistical methodology all revealed a significant association between high expression of c-Met and OS in patients with EC. CONCLUSIONSː The current evidence indicated that c-Met overexpression is significantly associated with a poorer prognosis in EC. C-Met may serve as a potential novel prognostic biomarker for EC patients.

      Pubmed     Full text   Copy Citation     Plaintext  

      Add institutional full text...

    Notes

     
    Knowledge, pearl, summary or comment to share?
    300 characters remaining
    help        
    You can also include formatting, links, images and footnotes in your notes
    • Simple formatting can be added to notes, such as *italics*, _underline_ or **bold**.
    • Superscript can be denoted by <sup>text</sup> and subscript <sub>text</sub>.
    • Numbered or bulleted lists can be created using either numbered lines 1. 2. 3., hyphens - or asterisks *.
    • Links can be included with: [my link to pubmed](http://pubmed.com)
    • Images can be included with: ![alt text](https://bestmedicaljournal.com/study_graph.jpg "Image Title Text")
    • For footnotes use [^1](This is a footnote.) inline.
    • Or use an inline reference [^1] to refer to a longer footnote elseweher in the document [^1]: This is a long footnote..

    hide…