• Pol. Merkur. Lekarski · Apr 2011

    [The cyclin A, B1, D1 and E expression in advanced non-small cell lung cancer--stages IIIB-IV (preliminary report)].

    • Monika Kosacka, Paweł Piesiak, Irena Porebska, Anna Korzeniewska, and Renata Jankowska.
    • Akademia Medyczna we Wrocławiu, Katedra i Klinika Pulmonologii i Nowotworów Płuc. mika113@tlen.pl
    • Pol. Merkur. Lekarski. 2011 Apr 1; 30 (178): 253-8.

    UnlabelledLung cancer is the leading cause of cancer death in the majority of developed countries. Uncontrolled cell proliferation is the hallmark of malignant tumours. Cyclins play an important role in cell cycle regulation. The aim of this study was to evaluate the expression of cyclins A, B1, D1 and E in advanced non-small cell lung cancer (stages IIIB-IV) with its prognostic significance.Material And MethodAn immunohistochemical assessment of cyclins A, B1, D1 and E expression was performed in the paraffin-embedded tumor tissues of 19 patients (9 men and 10 women). The mean was age 59 +/- 6.64 years. 9 patients were in IIIB and 10 in IV. The 2-years survival rate was evaluated.ResultsWe showed positive cyclin A expression in 13 tumor tissue specimens (68%), cyclin B1 in 3 (16%), cyclin D1 in 9 (47%) and cyclin E in 7 (37%). We analyzed the prognostic value of examinated cyclins in all NSCLC patients and separately in patients with squamous cell lung cancer and adenocarcinoma and in patients in stage IIIB and IV, but we have no found any correlations. We did not find also any differences in examinated cyclins expression depending on stages nor different histopathological types.ConclusionWe did not observe prognostic value of cyclins A, B1, D1 or E expression in advanced non-small cell lung cancer.

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