• J. Am. Coll. Cardiol. · Nov 2015

    Early and Late Outcomes of Surgical Treatment in Carcinoid Heart Disease.

    • Heidi M Connolly, Hartzell V Schaff, Martin D Abel, Joseph Rubin, J Wells Askew, Zhuo Li, Jacob J Inda, Sushil A Luis, Rick A Nishimura, and Patricia A Pellikka.
    • Division of Cardiovascular Diseases, Mayo Clinic, Rochester, Minnesota. Electronic address: connolly.heidi@mayo.edu.
    • J. Am. Coll. Cardiol. 2015 Nov 17; 66 (20): 2189-2196.

    BackgroundSymptoms and survival of patients with carcinoid syndrome have improved, but development of carcinoid heart disease (CaHD) continues to decrease survival.ObjectivesThis study aimed to analyze patient outcomes after valve surgery for CaHD during a 27-year period at 1 institution to determine early and late outcomes and opportunities for improved patient care.MethodsWe retrospectively studied the short-term and long-term outcomes of all consecutive patients with CaHD who underwent valve replacement at our institution between 1985 and 2012.ResultsThe records of 195 patients with CaHD were analyzed. Pre-operative New York Heart Association class was III or IV in 125 of 178 patients (70%). All had tricuspid valve replacement (159 bioprostheses, 36 mechanical), and 157 underwent a pulmonary valve operation. Other concomitant operations included mitral valve procedure (11%), aortic valve procedure (9%), patent foramen ovale or atrial septal defect closure (23%), cardiac metastasectomies or biopsy (4%), and simultaneous coronary artery bypass (11%). There were 20 perioperative deaths (10%); after 2000, perioperative mortality was 6%. Survival rates (95% confidence intervals) at 1, 5, and 10 years were 69% (63% to 76%), 35% (28% to 43%), and 24% (18% to 32%), respectively. Overall mortality was associated with older age, cytotoxic chemotherapy, and tobacco use; 75% of survivors had symptomatic improvement at follow-up. Presymptomatic valve operation was not associated with late survival benefit.ConclusionsOperative mortality associated with valve replacement surgery for CaHD has decreased. Symptomatic and survival benefit is noted in most patients when CaHD is managed by an experienced multidisciplinary team.Copyright © 2015 American College of Cardiology Foundation. Published by Elsevier Inc. All rights reserved.

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