• Maki Komiyama, Hajime Yamakage, Noriko Satoh-Asahara, Yuka Ozaki, Tatsuya Morimoto, Akira Shimatsu, Yuko Takahashi, and Koji Hasegawa.
• Clinical Research Institute, National Hospital Organization Kyoto Medical Center, Kyoto 612-8555, Japan. Electronic address: nikonikomakirin@yahoo.co.jp.
• Psychiatry Res. 2018 Sep 1; 267: 154-159.

AbstractDepressive tendency and nicotine dependency are factors related to the failure of smoking cessation. Women generally have a higher depressive tendency and difficulty in smoking cessation than men. However, the impact of sex differences on the relationship between nicotine dependency and depressive tendency remains unclear. We evaluated 727 patients (496 men and 231 women) who visited our outpatient clinic for smoking cessation therapy and compared various parameters measured between sexes during consultation. Age, duration of smoking, and daily cigarette consumption were significantly higher in men during the first visit. Women had significantly higher self-rating depression scale (SDS) scores and took significantly more antidepressant drugs than men. The SDS score significantly correlated with the Fagerström test for the nicotine dependence score and with daily cigarette consumption in women, but not in men. Thus, the present study demonstrates the differential relationship of depressive tendency with tobacco use or nicotine dependency in men and women, which might reflect sex differences in response to psychological stress.Copyright © 2018 Elsevier B.V. All rights reserved.

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