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Eur. J. Clin. Microbiol. Infect. Dis. · Feb 2021
Practical challenges to the clinical implementation of saliva for SARS-CoV-2 detection.
- Nancy Matic, Aleksandra Stefanovic, Victor Leung, Tanya Lawson, Gordon Ritchie, Lynne Li, Sylvie Champagne, Marc G Romney, and Christopher F Lowe.
- Division of Medical Microbiology and Virology, Providence Health Care, St. Paul's Hospital, 1081 Burrard St., Vancouver, BC, V6Z 1Y6, Canada. nmatic@providencehealth.bc.ca.
- Eur. J. Clin. Microbiol. Infect. Dis. 2021 Feb 1; 40 (2): 447-450.
AbstractDue to global shortages of flocked nasopharyngeal swabs and appropriate viral transport media during the COVID-19 pandemic, alternate diagnostic specimens for SARS-CoV-2 detection are sought. The accuracy and feasibility of saliva samples collected and transported without specialized collection devices or media were evaluated. Saliva demonstrated good concordance with paired nasopharyngeal swabs for SARS-CoV-2 detection in 67/74 cases (90.5%), though barriers to saliva collection were observed in long-term care residents and outbreak settings. SARS-CoV-2 RNA was stable in human saliva at room temperature for up to 48 h after initial specimen collection, informing appropriate transport time and conditions.
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