• Zeming Liu, Jinpeng Li, Jianglong Huang, Liang Guo, Rongfen Gao, Kuan Luo, Guang Zeng, Tingbao Zhang, Meilin Yi, Yihui Huang, Jincao Chen, Yibin Yang, and Xiaohui Wu.
• Department of Plastic Surgery, Zhongnan Hospital of Wuhan University, Wuhan, China.
• Front Endocrinol (Lausanne). 2020 Jan 1; 11: 478.

AbstractAims: This study aimed to investigate the clinical courses and outcomes of diabetes mellitus patients with coronavirus disease 2019 (COVID-19) in Wuhan. Methods: This study enrolled 1,880 consecutive patients with confirmed COVID-19 in Leishenshan Hospital. We collected and analyzed their data, including demographic data, history of comorbidity, clinical symptoms, laboratory tests, chest computed tomography (CT) images, treatment options, and survival. Results: The percentages of patients with diabetes among the severe and critical COVID-19 cases were higher than those among the mild or general cases (89.2%, 10.8 vs. 0%, p = 0.001). However, patients with and without diabetes showed no difference in the follow-up period (p = 0.993). The mortality rate in patients with or without diabetes was 2.9% (n = 4) and 1.1% (n = 9), respectively (p = 0.114). Univariate and multivariate Cox regression analyses and the Kaplan-Meier curves did not show any statistically significant differences between patients with and without diabetes (all p > 0.05). Conclusions: Our study results suggested that diabetes had no effect on the prognosis of COVID-19 patients but had a negative association with their clinical courses. These results may be useful for clinicians in the management of diabetic patients with COVID-19.Copyright © 2020 Liu, Li, Huang, Guo, Gao, Luo, Zeng, Zhang, Yi, Huang, Chen, Yang and Wu.

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