• Indian heart journal · Nov 2017

    Randomized Controlled Trial

    Use of nitroglycerin and verapamil solution by organ bath technique in preparation of left internal thoracic artery for coronary artery bypass surgery.

    • Ray Mohapatra Chandan Kumar CK Department of Cardiovascular & Thoracic Surgery, Lokmanya Tilak Municipal Medical College & Sion Hospital, Mumbai, India. Electronic addres, Prashant Mishra, Pankaj Saxena, Chaitanya Raut, Jayant Khandekar, Ganesh Kumar Ammannaya, Harsh S Seth, Vaibhav Shah, and Jaskaran Singh.
    • Department of Cardiovascular & Thoracic Surgery, Lokmanya Tilak Municipal Medical College & Sion Hospital, Mumbai, India. Electronic address: bapun39@gmail.com.
    • Indian Heart J. 2017 Nov 1; 69 (6): 772-776.

    BackgroundThe aim of this prospective study was to compare the effect of application of nitroglycerin and verapamil solution (GV) by organ bath technique with other methods of applications and solutions on the free blood flow of LITA. The technique was not described for in situ graft before.MethodThe patients were randomly assigned to four groups: group I (n_32, GV solution by organ bath technique), group II (n_30, papaverine solution by organ bath technique), group III (n_29, topical GV solution) or group IV (n_29, topical papaverine solution). In each patient, pedicled LITA was harvested; thereafter applied with the randomized different methods and solutions. The free flow from the distal end of the divided LITA was measured for 15s under controlled hemodynamic conditions after harvesting (Flow 1). The flow of LITA was measured again just prior to anastomosing the conduit (Flow 2).ResultThe mean blood flow in LITA was 56.2±5.0ml/min before application of solutions. After application, the mean blood flow in group I:102.3±7.0ml/min, in group II: 92.7±3.4ml/min, and in group III: 88.6±2.2ml/min and in group IV: 81.4±2.1. Proportional increases in blood flow observed in group I (82.6%)>group II (65.1%)>group III (57.6)>group IV (44.8%) (p<0.05).ConclusionsGV solution by organ bath technique is effective and superior in comparison to use of papaverine using organ bath technique or topical spray of GV or papaverine solution.Copyright © 2017 Cardiological Society of India. All rights reserved.

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