• Y Wang, S Zhong, Y Jia, Z Zhou, Q Zhou, and L Huang.
• Clinical Experimental Center, First Affiliated Hospital of Jinan University, Guangzhou, China.
• Acta Psychiatr Scand. 2015 Nov 1; 132 (5): 400-7.

ObjectiveAbnormalities in structural and functional brain connectivity have been increasingly reported in patients with bipolar disorder (BD) by recent neuroimaging studies. However, relatively little is known about the changes in functional interaction between the cerebral hemispheres in BD. The present study aimed to examine the interhemispheric functional connectivity of the whole brain in patients with BD II during resting state.MethodTwenty-six patients with unmedicated BD II depression and 40 normal controls underwent the resting-state functional magnetic resonance imaging. The functional connectivity between any pair of symmetrical interhemispheric voxels (i.e., functional homotopy) was measured by voxel-mirrored homotopic connectivity (VMHC).ResultsThe patients with BD II showed lower VMHC than normal controls in the medial prefrontal cortex and inferior temporal gyrus. No regions of increased VMHC were detected in patients. There were no significant correlations between the VMHC values in these regions and clinical severity of BD symptoms.ConclusionThese findings suggest substantial impairment of interhemispheric coordination in BD II.© 2015 John Wiley & Sons A/S. Published by John Wiley & Sons Ltd.

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