• Alex Rua Rodrigues, Damila Cristina Trufelli, Fernando Fonseca, Larissa Carvalho de Paula, and Giglio Auro Del AD Faculdade de Medicina do ABC, Santo André, Brazil aurodelgiglio@gmail.com..
• Faculdade de Medicina do ABC, Santo André, Brazil.
• Am J Hosp Palliat Care. 2016 Dec 1; 33 (10): 942-947.

PurposeTo assess which laboratory and clinical factors are associated with fatigue in patients with terminal cancer.MethodsWe evaluated 51 patients with advanced incurable solid tumors using the Chalder Fatigue Questionnaire (CFQ) and the Functional Assessment of Chronic Illness Therapy-Fatigue (FACIT-F) scale for fatigue; the Pittsburgh Sleep Quality Index (PSQI-BR) for sleep quality; the Hospital Anxiety and Depression Scale (HADS) for anxiety and depression; the European Organization for Research and Treatment of Cancer (EORTC) Core Quality of Life Questionnaire, Version 3.0 (QLQ C-30); and Functional Assessment of Cancer Therapy (FACT) for quality of life. We also analyzed several inflammatory markers and the modified Glasgow prognostic score (mGPS).ResultsWe observed severe fatigue in 19 (38%) patients (FACIT-F score >36). There was a significant correlation between fatigue as evaluated by the CFQ and quality of sleep and between the CFQ mental fatigue subscale scores and TNF-α level. When fatigue was evaluated using the FACIT-F scale, we observed a significant association between fatigue and anxiety/depression, quality of sleep, mGPS, and hemoglobin levels. Fatigue measured both with the CFQ and FACIT-F scale correlated with poor quality of life according to the EORTC QLQ C-30.ConclusionIn patients with advanced cancer, fatigue is a common symptom associated with the presence of inflammation, poor quality of sleep, depression/anxiety, and poor quality of life.© The Author(s) 2015.

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