• Supatra Leelaphiwat, Theerayut Jongwutiwes, Srithean Lertvikool, Chotika Tabcharoen, Matchuporn Sukprasert, Sasivimol Rattanasiri, and Sawaek Weerakiet.
• Department of Pathology, Faculty of Medicine Ramathibodi Hospital, Mahidol University, Bangkok, Thailand.
• J. Obstet. Gynaecol. Res. 2015 Mar 1; 41 (3): 402-10.

AimTo compare the effects of ethinyl estradiol (EE) 30 mcg/desogestrel 150 mcg plus spironolactone 25 mg/day (group A) versus EE 35 mcg/cyproterone acetate 2 mg (group B) on hyperandrogenism and metabolism in PCOS.MethodsThis was a randomized clinical study. Eighteen women in groups A and B received medications for three cycles. Acne score, androgens and metabolic parameters were assessed before and after treatment.ResultsOne and two women in groups A and B, respectively, were excluded from the study. Both groups had significantly decreased acne score and free androgen index, and increased sex hormone-binding globulin levels. Cholesterol and high-density lipoprotein were significantly increased in group B, and androstenedione was significantly decreased in group A. The regular withdrawal bleeding was obtained in both groups.ConclusionBoth regimens had quite similar efficacy on hyperandrogenism after three cycles of therapy and without any changes in metabolic parameters.© 2014 The Authors. Journal of Obstetrics and Gynaecology Research © 2014 Japan Society of Obstetrics and Gynecology.

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