• The American surgeon · Sep 2011

    Biography Historical Article

    Gangrene therapy and antisepsis before lister: the civil war contributions of Middleton Goldsmith of Louisville.

    • John M Trombold.
    • Department of Surgery, University of Louisville, Louisville, Kentucky, USA. Jmtrom01@louisville.edu
    • Am Surg. 2011 Sep 1; 77 (9): 1138-43.

    AbstractIt is commonly accepted that Louis Pasteur is the father of microbiology and Joseph Lister is the father of antisepsis. Middleton Goldsmith, a surgeon in the Union Army during the American Civil War, meticulously studied hospital gangrene and developed a revolutionary treatment regimen. The cumulative Civil War hospital gangrene mortality was 45 per cent. Goldsmith's method, which he applied to over 330 cases, yielded a mortality under 3 per cent. His innovative work predated Pasteur and Lister, making his success truly remarkable and worthy of historical and surgical note.

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