• Biomarkers in medicine · Aug 2018

    Review

    Predictive biomarkers of chemotherapy-induced peripheral neuropathy: a review.

    • Patrick L Diaz, Anthony Furfari, Bo Angela Wan, Henry Lam, George Charames, Leah Drost, Angelo Fefekos, Shannon Ohearn, Alexia Blake, Rashi Asthana, Edward Chow, and Carlo DeAngelis.
    • Sunnybrook Health Sciences Centre, University of Toronto, Toronto, Ontario, M4N 3M5, Canada.
    • Biomark Med. 2018 Aug 1; 12 (8): 907-916.

    AbstractChemotherapy-induced peripheral neuropathy (CIPN) is a common side effect of taxane treatment during chemotherapy. Identifying predictive biomarkers of CIPN would allow physicians to alter treatment given to patients according to a personal risk of developing this condition. The current literature on CIPN biomarkers is reviewed, identifying biomarkers which have been found to be significantly related to CIPN. Three genetic biomarkers are identified (ARHGEF10 rs9657362, CYP2C8 rs11572080/rs10509681 and FGD4 rs10771973) which have been found to act as predictive CIPN biomarkers in multiple studies. Possible mechanisms underlying the relationship between these single nucleotide polymorphisms and CIPN development are explored. The biomarkers identified in this study should be investigated further to generate predictive biomarkers that may be used in a clinical setting.

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