• J Oncol Pharm Pract · Dec 2016

    Chemotherapy drug shortages in paediatric oncology: A 14-year single-centre experience in Belgium.

    • Tiene Bauters, Barbara Om Claus, Koen Norga, Isabelle Huys, Steven Simoens, and Geneviève Laureys.
    • Department of Pediatric Hemato-Oncology and Stem Cell Transplantation, Ghent University Hospital, Ghent, Belgium Department of Pharmacy, Ghent University Hospital, Ghent, Belgium tiene.bauters@uzgent.be.
    • J Oncol Pharm Pract. 2016 Dec 1; 22 (6): 766-770.

    AbstractShortages of chemotherapy are a growing challenge for the healthcare system. We present the burden of drug shortages of chemotherapeutics in the paediatric hemato-oncology unit of a tertiary care hospital and solutions that were used to manage them. Between January 2001 and December 2014, 54 individual shortages were detected, affecting a total number of 21 different drugs. In total, 4127 shortage days were registered with a mean duration of 196.5 SD ± 144.0 days per individual drug shortage. Methotrexate, doxorubicin and carboplatin had the longest supply disruptions. Solutions to address the problems were purchase of a generic alternative, a change of individual treatment plans, cohorting of patients and import from abroad.© The Author(s) 2015.

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