• Am J Otolaryngol · Jan 2012

    Case Reports

    Aggressive sinonasal natural killer/T-cell lymphoma with hemophagocytic lymphohistiocytosis.

    • Justin H Turner, Myriam Loyo, and Sandra Y Lin.
    • Department of Otolaryngology-Head and Neck Surgery, The Johns Hopkins University School of Medicine, Baltimore, MD 21287, USA. justin.turner@jhmi.edu
    • Am J Otolaryngol. 2012 Jan 1; 33 (1): 188-91.

    AbstractExtranodal natural killer/T-cell lymphoma of the nasal cavity is a rare malignancy with poor overall prognosis. We report the case of a rapidly fatal natural killer/T-cell lymphoma of the nasal cavity complicated by the concominant development of hemophagocytic lymphohistiocytosis. This disorder is marked by clinical findings such as fever and splenomegaly, a multitude of abnormal laboratory findings, and a profound proliferation of circulating macrophages. Left untreated, multi-organ failure and death are common. Prompt diagnosis is essential to the successful management of this disorder and for subsequent recovery.Copyright © 2012 Elsevier Inc. All rights reserved.

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