• Jessica Gill, Lawrence Latour, Ramon Diaz-Arrastia, Vida Motamedi, Christine Turtzo, Pashtun Shahim, Stefania Mondello, Christina DeVoto, Eliseo Veras, David Hanlon, Linan Song, and Andreas Jeromin.
• From the National Institutes of Health (J.G., V.M., C.D.), National Institute of Nursing Research, the Center for Neuroscience and Regenerative Medicine (J.G., P.S.), Uniformed Services University of the Health Sciences, Biomarker Core, and the National Institutes of Health (L.L., C.T.), National Institute of Neurological Disorders and Stroke, Bethesda, MD; the Department of Neurology (R.D.-A.), University of Pennsylvania, Philadelphia, PA; the Department of Biomedical and Dental Sciences and Morphofunctional Imaging (S.M.), University of Messina, Italy; and the Quanterix Corporation (E.V., D.H., L.S., A.J.), Lexington, MA. gillj@mail.nih.gov.
• Neurology. 2018 Oct 9; 91 (15): e1385-e1389.

ObjectivesTo determine whether a panel of blood-based biomarkers can discriminate between patients with suspected mild traumatic brain injury (mTBI) with and without neuroimaging findings (CT and MRI).MethodsStudy participants presented to the emergency department with suspected mTBI (n = 277) with a CT and MRI scan and healthy controls (n = 49). Plasma concentrations of tau, glial fibrillary acidic protein (GFAP), ubiquitin carboxyl-terminal hydrolase L1, and neurofilament light chain (NFL) were measured using the single-molecule array technology.ResultsConcentrations of GFAP, tau, and NFL were higher in patients with mTBI, compared with those of controls (p's < 0.01). GFAP yielded an area under the curve (AUC) of 0.93 (95% confidence interval [CI] 0.90-0.96), confirming its discriminatory power for distinguishing mTBI from controls. Levels of GFAP, tau, and NFL were higher in patients with trauma-related intracranial findings on CT compared with those with normal CT, with the only significant predictor being GFAP (AUC 0.77, 95% CI 0.70-0.84). Among patients with mTBI, tau, NFL, and GFAP differentiated subjects with and without MRI abnormalities with an AUC of 0.83, with GFAP being the strongest predictor. Combining tau, NFL, and GFAP showed a good discriminatory power (AUC 0.80, 95% CI 0.69-0.90) for detecting MRI abnormalities, even in patients with mTBI with a normal CT.ConclusionOur study confirms GFAP as a promising marker of brain injury in patients with acute mTBI. A combination of various biomarkers linked to different pathophysiologic mechanisms increases diagnostic subgroup accuracy. This multimarker strategy may guide medical decision making, facilitate the use of MRI scanning, and prove valuable in the stratification of patients with brain injuries in future clinical trials.Classification Of EvidenceClass I evidence that blood concentrations of GFAP, tau, and NFL discriminate patients with mTBI with and without neuroimaging findings.© 2018 American Academy of Neurology.

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