• Ju-Dong Li, Xin-Fei Xu, Jun Han, Han Wu, Hao Xing, Chao Li, Jiong-Jie Yu, Ya-Hao Zhou, Wei-Min Gu, Hong Wang, Ting-Hao Chen, Yong-Yi Zeng, Wan Y Lau, Meng-Chao Wu, Feng Shen, and Tian Yang.
• Department of Hepatobiliary Surgery, Eastern Hepatobiliary Surgery Hospital, Second Military Medical University, Shanghai, China; Department of Clinical Medicine, Second Military Medical University, Shanghai, China.
• HPB (Oxford). 2019 Feb 1; 21 (2): 157-166.

BackgroundSerum prealbumin is a sensitive and stable marker for nutritional status and liver function. Whether preoperative prealbumin level is associated with long-term prognosis in patients undergoing liver resection for hepatocellular carcinoma (HCC) is unclear.MethodsPatients who underwent liver resection for HCC between 2001 and 2014 at six institutions were enrolled. These patients were divided into the low and normal prealbumin groups using a cut-off value of 170 mg/L for preoperative prealbumin level. The overall survival (OS) and recurrence-free survival (RFS) were compared between them.ResultsIn 1483 patients, 437 (29%) had a low prealbumin level. The 3- and 5-year OS and RFS rates of patients in the low-prealbumin group were 57 and 31%, and 40 and 20%, respectively, which were significantly poorer than those in the normal-prealbumin group (76 and 43%, and 56 and 28%, respectively, both p < 0.001). Multivariable Cox-regression analyses revealed that preoperative prealbumin level was an independent predictor of OS (HR, 1.45, 95% CI: 1.24-1.70, p <0.001) and RFS (HR, 1.28, 95% CI: 1.10-1.48, p <0.001).ConclusionsPreoperative prealbumin level could be used in predicting long-term prognosis for patients undergoing liver resection for HCC.Copyright © 2018 International Hepato-Pancreato-Biliary Association Inc. Published by Elsevier Ltd. All rights reserved.

31 keywords...

hide…