• Sumitra Ganesh Bakshi, Bipin Jibhkate, Raman Sareen, and Rajan Badwe.
• Department of Anesthesia, Critical Care and Pain, Tata Memorial Hospital, Mumbai, India. sumitrabakshi@yahoo.in
• J Anesth. 2012 Apr 1;26(2):187-95.

BackgroundBreast surgery is associated with frequent post-operative nausea and vomiting (PONV). Studies have suggested that hormonal status affects PONV. Estrogen has been implicated in many emetic syndromes. Estrogen receptor (ER) and progesterone receptor (PR) status in breast tissue are hormonally affected. Kakugawa et al., in 2007, found a clear trend toward higher serum level of estrone, estradiol, and dehydroepiandrosterone sulfate in post menopausal women with PR-positive cancer.PurposeTo investigate the possibility of an association between ER and/or PR status of breast tumor and incidence of PONV after breast cancer surgery.MethodsThis observational study included 315 female patients undergoing major breast surgery. Relevant patient data, and intra-operative and postoperative details were noted. Incidence of PONV was noted using the PONV score. Patients were divided into two age groups: less than or equal to 50 years and more than 50 years of age. The ER and/or PR status of the patient was unknown to the investigator until the final analysis.ResultsUse of the chi-squared test revealed no association between ER and/or PR and total PONV. Patients below 50 years had higher incidence of total PONV (p = 0.023). In patients above 50 years, the incidence of PONV was higher in the ER-positive group (p = 0.018).ConclusionThe incidence of PONV is higher for patients below 50 years of age. The positive association between ER positivity and PONV in patients above 50 years of age could be attributed to the altered hormonal milieu in these patients and should be investigated further.

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