• Farid Rashidi, Stefano Barco, Farin Kamangar, Gustavo A Heresi, Ashkan Emadi, Cihangir Kaymaz, Pavel Jansa, Abilio Reis, Arash Rashidi, Ali Taghizadieh, Parisa Rezaeifar, Minoosh Moghimi, Samad Ghodrati, Abolfazl Mozafari, Ali Alavi Foumani, Ouria Tahamtan, Effat Rafiee, Zahra Abbaspour, Kasra Khodadadi, Golsa Alamdari, Yasman Boodaghi, Maryam Rezaei, Muhammad Javad Muhammadi, Meysam Abbasi, Fatemeh Movaseghi, Ata Koohi, Leila Shakourzad, Fatemeh Ebrahimi, Sarvin Radvar, Maryam Amoozadeh, Fatemeh Fereidooni, Hanieh Naseari, Kobra Movalled, Ozra Ghorbani, and Khalil Ansarin.
• Tuberculosis and Lung Disease Research Center, Tabriz University of Medical Sciences, Tabriz, Iran. Electronic address: fr2652@yahoo.com.
• Thromb. Res. 2021 Feb 1; 198: 135-138.

BackgroundThrombosis and pulmonary embolism appear to be major causes of mortality in hospitalized coronavirus disease 2019 (COVID-19) patients. However, few studies have focused on the incidence of venous thromboembolism (VTE) after hospitalization for COVID-19.MethodsIn this multi-center study, we followed 1529 COVID-19 patients for at least 45 days after hospital discharge, who underwent routine telephone follow-up. In case of signs or symptoms of pulmonary embolism (PE) or deep vein thrombosis (DVT), they were invited for an in-hospital visit with a pulmonologist. The primary outcome was symptomatic VTE within 45 days of hospital discharge.ResultsOf 1529 COVID-19 patients discharged from hospital, a total of 228 (14.9%) reported potential signs or symptoms of PE or DVT and were seen for an in-hospital visit. Of these, 13 and 12 received Doppler ultrasounds or pulmonary CT angiography, respectively, of whom only one patient was diagnosed with symptomatic PE. Of 51 (3.3%) patients who died after discharge, two deaths were attributed to VTE corresponding to a 45-day cumulative rate of symptomatic VTE of 0.2% (95%CI 0.1%-0.6%; n = 3). There was no evidence of acute respiratory distress syndrome (ARDS) in these patients. Other deaths after hospital discharge included myocardial infarction (n = 13), heart failure (n = 9), and stroke (n = 9).ConclusionsWe did not observe a high rate of symptomatic VTE in COVID-19 patients after hospital discharge. Routine extended thromboprophylaxis after hospitalization for COVID-19 may not have a net clinical benefit. Randomized trials may be warranted.Copyright © 2020 Elsevier Ltd. All rights reserved.

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