• Forensic Sci. Int. · Apr 2003

    Case Reports

    An autopsy case of combined drug intoxication involving verapamil, metoprolol and digoxin.

    • Hiroshi Kinoshita, Tadaaki Taniguchi, Minori Nishiguchi, Harumi Ouchi, Takako Minami, Takao Utsumi, Hiroyuki Motomura, Toyohiko Tsuda, Takehiko Ohta, Shigeru Aoki, Motoo Komeda, Tetsuji Kamamoto, Akira Kubota, Chiaki Fuke, Tomonori Arao, Tetsuji Miyazaki, and Shigeru Hishida.
    • Department of Legal Medicine, Hyogo College of Medicine, 1-1 Mukogawa-cho, Nishinomiya, Hyogo 663-8501, Japan. kinochin@hyo-med.ac.jp
    • Forensic Sci. Int. 2003 Apr 23; 133 (1-2): 107-12.

    AbstractWe present here a fatal poisoning case involving verapamil, metoprolol and digoxin. A 39-year-old male was found dead in his room, and a lot of empty packets of prescribed drugs were found near the corpse. The blood concentrations of verapamil, metoprolol and digoxin were 9.2 microg/ml, 3.6 microg/ml and 3.2 ng/ml, respectively. The cause of death was given as cardiac failure, hypotension and bradycardia due to a mixed drug overdose of verapamil, metoprolol and digoxin, based on the results of the autopsy and toxicological examination. We speculate that the toxicity of verapamil is potentiated by drug interaction with metoprolol and digoxin.

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