• Hong-Bin Chen and Xiao-Ying Su.
• Department of Gastroenterology.
• Medicine (Baltimore). 2019 Sep 1; 98 (39): e17295.

BackgroundIn this study, investigators will evaluate the efficacy and safety of lactulose for the treatment of irritable bowel syndrome (IBS).MethodsLiterature search for relevant studies up to present will be conducted in MEDICINE, EMBASE, Google Scholar, Web of Science, Cochrane Library, Wangfang, Allied and Complementary Medicine Database, Chinese Biomedical Literature Database, and China National Knowledge Infrastructure. The included studies are randomized controlled trials of lactulose in patients with IBS. We will use RevMan 5.3 software using statistical analysis.ResultsThis study will provide a high-quality integration of current evidence of lactulose for treating IBS on several aspects including global IBS symptoms, abdominal pain, defecation urgency, stool frequency, stool consistency, quality of life, and adverse events.ConclusionsThis study will provide the evidence for the clinical efficacy and safety of lactulose for the treatment of IBS.Prospero Registration NumberPROSPERO CRD42019140639.

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