• Alondra Frías Oyarzún, Paula Segura Hidalgo, Luis Toro Cabrera, Leticia Elgueta Segura, Rubén Torres Díaz, and Miriam Alvo Abodovsky.
• Hospital Clínico, Universidad de Chile, Santiago, Chile.
• Rev Med Chil. 2021 Jan 1; 149 (1): 7-12.

BackgroundThe discovery of the phospholipase A2 receptor antigen and its highly specific autoantibody (anti-PLA2R Ab) was useful for the diagnosis and follow-up of patients with membranous nephropathy (MN). Thus, some international guidelines recommend not performing renal biopsy in patients with positive serum anti-PLA2R Ab.AimTo evaluate the prevalence of anti-PLA2R Ab in serum and renal tissue samples from Chilean patients with primary MN.Material And MethodsTwenty-eight patients aged 50 ± 14 years (20 males) with biopsy-proven primary MN plus a negative workup for secondary causes were included. Measurements of serum and renal histologic anti-PLA2R Ab were performed. The relationship between the findings of serum and tissue anti-PLA2R Ab was evaluated.ResultsFifteen patients (54 %) had anti-PLA2R Ab presence in serum and 19 patients (68%) had positive anti-PLA2R Ab in the renal biopsy. All patients with positive serum anti-PLA2R Ab had positive antibodies on immunohistochemistry.ConclusionsSerum anti-PLA2R Ab is potentially useful in the diagnosis of patients with suspected primary MN in Chilean population.

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