• Andreas P Berger, Martina Deibl, Hannes Steiner, Jasmin Bektic, Alexandre Pelzer, Robert Spranger, Helmut Klocker, Georg Bartsch, and Wolfgang Horninger.
• Department of Urology, University of Innsbruck, Innsbruck, Austria. andreas.p.berger@uibk.ac.at
• Prostate. 2005 Aug 1; 64 (3): 240-5.

BackgroundTo determine longitudinal PSA changes over a period of 10 years in patients with and without prostate cancer.MethodsSerial PSA measurements performed over 10 years were evaluated in 353 men who eventually developed prostate cancer and in 2.462 participants of a screening program without prostatic malignancy.ResultsIn men with cancer, mean tPSA increased from 2.28 ng/ml at 10 years before diagnosis to 6.37 ng/ml at the time of postive biopsy (PSA velocity: 0.409 ng/ml/year). PSA velocity was significantly associated with Gleason scores and pathologic stage. In the benign group (n=2.462), mean tPSA increased from 1.18 to 1.49 ng/ml over a period of 10 years (PSA velocity of 0.03 ng/ml/year). Of the subjects with tPSA levels of 2 ng/ml or less, 2 years prior to cancer diagnosis, 11.4% had tPSA values of more than 4 ng/ml at the time of biopsy. Of the 972 men with tPSA below 1 ng/ml 2 years before the most recent measurement was obtained, 966 (99.4%) had no evidence of prostate cancer 2 years later, while six were found to have malignancies (0.6%).ConclusionsLongitudinal PSA changes in men with and without prostate cancer are significantly different. Annual testing may not be required in men with baseline tPSA levels of 1 ng/ml or below, whereas in patients with levels higher than 1 ng/ml, it seems to be indicated because of the significant percentage of men presenting with tPSA levels of more than 4 ng/ml two years later.(c) 2005 Wiley-Liss, Inc.

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