• Annals of hematology · Mar 2010

    Review Case Reports

    Sheehan's syndrome with pancytopenia--complete recovery after hormone replacement (case series with review).

    • Bashir Ahmad Laway, Javid Rasool Bhat, Shahnaz Ahmad Mir, Raja Sultan Zaman Khan, Mohd Iqbal Lone, and Abdul Hamid Zargar.
    • Department of Endocrinology, Sher-i-Kashmir Institute of Medical Sciences, Soura, Srinagar, Jammu and Kashmir, India.
    • Ann. Hematol. 2010 Mar 1; 89 (3): 305-8.

    AbstractReports of pancytopenia in patients with Sheehan's syndrome are rare, because the disorder is not commonly seen in western countries. A case series of pancytopenia in three patients of Sheehan's syndrome is presented. Three women aged 22, 30, and 34 years developed Sheehan's syndrome preceded by post partum hemorrhage. During investigations, they were found to have pancytopenia with hypocellular marrow. Treatment with thyroxine and glucocorticoids resulted in complete recovery after attaining euthyroid and eucortisolemic state. Review of literature revealed the rarity of the disorder, with only four cases reported so far. Multiple anterior pituitary hormone deficiencies in Sheehan's syndrome are responsible for pancytopenia; replacement of thyroid and cortisol hormones results in complete recovery.

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