• Metab. Clin. Exp. · Oct 2013

    Resistance training may concomitantly benefit body composition, blood pressure and muscle MMP-2 activity on the left ventricle of high-fat fed diet rats.

    • Richard Diego Leite, Rita de Cássia Marqueti Durigan, Anderson Diogo de Souza Lino, Markus Vinicius de Souza Campos, Maria das Graças Souza, Heloisa Silvestre Selistre-de-Araújo, Eliete Bouskela, and Luiz Guilherme Kraemer-Aguiar.
    • Departament of Physical Education, Federal University of Maranhão, São Luis, MA, Brazil; Clinical and Experimental Research Laboratory in Vascular Biology (BioVasc), Biomedical Center, State University of Rio de Janeiro, Rio de Janeiro, RJ, Brazil. Electronic address: rdleite@gmail.com.
    • Metab. Clin. Exp. 2013 Oct 1; 62 (10): 1477-84.

    ObjectiveThe purpose of this study was to evaluate the effect of resistance training (RT) on body composition, systolic and diastolic blood pressures (BP), and activity of muscle MMP-2 in the left ventricle of high-fat fed rats.Materials/MethodsWe have evaluated 32 male Wistar rats divided into four experimental groups (n=8/each) according to diet and exercise status: sedentary (SED; standard diet), sedentary obese (SED-OB; diet: 30% of fat), RT (RT; standard diet) and RT obese (RT-OB; diet: 30% of fat). After weaning (day 21), animals were subjected to the experimental diet according to their groups during 24 weeks. A 12-week strength-training period was used, during which the rats climbed a 1.1-m vertical ladder with weights attached to their tails. Sessions were performed three times/week (Mondays, Wednesdays and Fridays), with 4-9 climbs/session and 8-12 dynamic movements/climb.ResultsRT induced higher muscle MMP-2 activity in the left ventricle in RT and RT-OB groups. Moreover, this study demonstrated that RT promoted lower body and fat masses, fat percentage, systolic and diastolic BPs and higher fat free mass in both trained groups.ConclusionRT increased muscle MMP-2 activity in the left ventricle, induced positive changes on body composition and lowered BPs in high-fat diet fed rats, suggesting that it may be a useful tool to prevent alterations induced by high-fat diet consumption.Copyright © 2013 Elsevier Inc. All rights reserved.

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