• Edward J Vigmond, Shane Kimber, Go Suzuki, Peter Faris, and L Joshua Leon.
• Department of Electrical and Computer Engineering, University of Calgary, Calgary, Alberta, Canada. edward.vigmond@u-bordeaux1.fr
• Can J Cardiol. 2013 Sep 1; 29 (9): 1126-33.

BackgroundIt has been suggested that more-complex fibrillation requires higher energy shocks to terminate. Furthermore, animal studies have demonstrated that shock timing also plays a role. The objective of this study was to test these assertions in a clinical context.MethodsNear- and far-field electrograms were collected during defibrillation threshold testing. Fibrillation complexity was measured by quantifying the organization in the signals with wavelet-based methods, scaling exponent, and cross-correlation analysis. Receiver operator characteristic curves were used to determine predictive value. The effect of the phase at which defibrillation shocks were applied was also determined.ResultsNo measure was able to classify whether a particular shock would be successful. All performed very poorly. Shock timing played no role in defibrillation outcome.ConclusionsSignal organization of a local electrogram and phase of shock delivery do not relate to minimum defibrillation shock energy immediately after ventricular fibrillation onset.Copyright © 2013 Canadian Cardiovascular Society. Published by Elsevier Inc. All rights reserved.

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