• Nagla A El-Shitany, Steve Harakeh, Shaimaa M Badr-Eldin, Amina M Bagher, Basma Eid, Haifa Almukadi, Badrah S Alghamdi, Ahlam A Alahmadi, Nibal A Hassan, Nariman Sindi, Samar A Alghamdi, Hailah M Almohaimeed, Zuhair M Mohammedsaleh, Turki M Al-Shaikh, Mohammed S Almuhayawi, Soad S Ali, and Manal El-Hamamsy.
• Department of Pharmacology and Toxicology, Faculty of Pharmacy, King Abdulaziz University, Jeddah, Saudi Arabia.
• Int J Gen Med. 2021 Jan 1; 14: 1389-1401.

BackgroundThe Pfizer-BioNTech COVID-19 vaccine has recently received emergency approval from the US FDA. The mRNA technology was used to manufacture the Pfizer vaccine; however, as a pioneering technology that has never been used in the manufacture of vaccines, many people have concerns about the vaccine's side effects. Thus, the current study aimed to track the short-term side effects of the vaccine.MethodsThe information in this study was gathered by a Google Form-questionnaire (online survey). The results included the responses of 455 individuals, all of whom are Saudi Arabia inhabitants. Adverse effects of the vaccine were reported after the first and the second doses.ResultsThe most common symptoms were injection site pain, headaches, flu-like symptoms, fever, and tiredness. Less common side effects were a fast heartbeat, whole body aches, difficulty breathing, joint pain, chills, and drowsiness. Rare side effects include Bell's palsy and lymph nodes swelling and tenderness. Flu-like symptoms were more common among those under 60 years of age, while injection site pain was more frequent among recipients who were 60 years and older. The study revealed a significant increase in the number of females who suffered from the vaccine side effects compared to males. Difficulty of breathing was more reported among recipients who had been previously infected with the coronavirus compared to those who had not been previously infected.ConclusionMost of the side effects reported in this study were consistent with Pfizer's fact sheet for recipients and caregivers. Further studies are required to determine the long-term side effects.© 2021 El-Shitany et al.

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