• J N Love, D Hanfling, and J M Howell.
• Georgetown-George Washington Emergency Medicine Residency, Washington, DC, USA.
• Ann Emerg Med. 1996 Jul 1; 28 (1): 1-6.

Study ObjectiveTo evaluate the hemodynamic effects of calcium chloride in a canine model of acute propranolol toxicity.MethodsTwo minutes after the completion of a propranolol infusion (10 mg/kg), a bolus of .125 mL/kg 10% CaCl solution followed by an infusion of .375 mL/kg over the next 30 minutes or a bolus and subsequent infusion of an equivalent volume of normal saline solution was administered to each dog.ResultsCaCl yielded significant improvements in propranolol-induced decreases in cardiac index and stroke volume compared with saline solution-treated control animals (overall alpha = .05). Furthermore, CaCl administration resulted in earlier improvement in propranolol-induced alterations in mean arterial pressure, maximal left ventricular pressure change over time, and peripheral vascular resistance compared with saline solution (overall alpha = .05). We observed no difference between treatment groups in response to propranolol-induced bradycardia or QRS-interval prolongation.ConclusionIn this model of acute propranolol toxicity, CaCl therapy improved depressed hemodynamic status, mainly by a positive inotropic action.

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