• Clin J Oncol Nurs · Apr 2017

    Review

    Metastatic Colorectal Cancer: Management With Trifluridine/Tipiracil
.

    • Teresa White, Heidi Larson, Alexandra Minnella, and Howard S Hochster.
    • Yale University.
    • Clin J Oncol Nurs. 2017 Apr 1; 21 (2): E30-E37.

    BackgroundTreatment-related adverse events (AEs) are common in patients with metastatic colorectal cancer (mCRC) receiving chemotherapy. These AEs may affect patient adherence, particularly with completely oral regimens, such as trifluridine/tipiracil (TAS-102, Lonsurf®), an antimetabolite agent for patients with mCRC refractory or intolerant to standard therapies.
.ObjectivesThis article reviews strategies for promoting adherence and educating patients and caregivers about oral therapy with trifluridine/tipiracil. 
.MethodsRecommended strategies for managing AEs are reviewed, with a focus on the most common AEs reported in patients with mCRC receiving trifluridine/tipiracil in clinical trials.
.FindingsOncology nurses play an important role in educating and counseling patients regarding treatment and its potential side effects. Among patients with mCRC refractory or intolerant to standard therapies, trifluridine/tipiracil was found to have a favorable safety profile. It is associated with hematologic AEs as well as a low incidence of nausea, diarrhea, vomiting, anorexia, and fatigue.

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