• R J Verdugo, R S Salinas, J Castillo, and J G Cea.
• Departmento de Ciencias Neurologicas, Universidad de Chile, Santiago, Chile.
• Cochrane Db Syst Rev. 2003 Jan 1 (3): CD001552.

BackgroundCarpal tunnel syndrome results from entrapment of the median nerve in the wrist. Common symptoms are tingling, numbness, and pain in the hand that may radiate to the forearm or shoulder. Surgical treatment is widely preferred to non-surgical or conservative therapies for people who have overt symptoms, while mild cases are usually not treated.ObjectivesThe objective is to compare the efficacy of surgical treatment of carpal tunnel syndrome with non-surgical treatment.Search StrategyWe searched the Cochrane Neuromuscular Disease Group trials register and MEDLINE, EMBASE and LILACS (to October 2002). We checked bibliographies in papers and contacted authors for information about other published or unpublished studies.Selection CriteriaWe included all randomised and quasi-randomised controlled trials comparing any surgical and any non-surgical therapies.Data Collection And AnalysisTwo reviewers independently assessed the eligibility of the trials.Main ResultsWe found two randomised controlled trials involving 198 participants in total. The first trial included 22 participants, 11 allocated to surgery and 11 to splinting for one month. The trial was not blinded nor was it clear if allocation was properly concealed. In the second trial, 87 participants were allocated to surgery and 89 to splinting for at least six weeks. The trial was not blinded but allocation concealment was adequate. The second trial considered our primary outcome measure, relevant clinical improvement at three months. Sixty-two people out of 87 allocated to surgery (71%) qualified for treatment success. Forty-six people out of 89 allocated to splinting (51.6%) qualified for treatment success. The confidence interval favoured the surgical group (relative risk 1.38 95% confidence interval 1.08 to 1.75). We were able to pool data from both trials for two secondary outcomes. For clinical improvement at one year of follow-up, the pooled estimate favoured surgery (relative risk 1.27, 95% confidence intervals 1.05 to 1.53). For need for surgery during follow-up, the pooled estimate indicates that a significant proportion of people treated medically will require surgery while the risk of re-operation in surgically treated people is low (relative risk 0.04 in favour of surgery, 95% confidence intervals 0.01 to 0.17).Reviewer's ConclusionsSurgical treatment of carpal tunnel syndrome relieves symptoms significantly better than splinting. Further research is needed to discover whether this conclusion applies to people with mild symptoms.

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