• Therapie · Jul 2020

    Review

    Challenges of autoimmune rheumatic disease treatment during the COVID-19 pandemic: A review.

    • Lucile Grange, Philippe Guilpain, Marie-Elise Truchetet, Jean-Luc Cracowski, and French Society of Pharmacology and Therapeutics.
    • University Saint-Étienne, 42000 Saint-Étienne, France.
    • Therapie. 2020 Jul 1; 75 (4): 335-342.

    AbstractSince December 2019, the COVID-19 pandemic has become a major public health problem. To date, there is no evidence of a higher incidence of COVID in patients with autoimmune rheumatic diseases and we support the approach of maintaining chronic rheumatological treatments. However, once infected there is a small but significant increased risk of mortality. Among the different treatments, NSAIDs are associated with higher rates of complications, but data for other drugs are conflicting or incomplete. The use of certain drugs for autoimmune inflammatory rheumatisms appears to be a potentially interesting options for the treatment. The rationale for their use is based on the immune system runaway and the secretion of pro-inflammatory cytokines (Il1, IL6, TNFα) in severe forms of the disease. Notably, patients on chloroquine or hydroxychloroquine as a treatment for their autoimmune rheumatic disease are not protected from COVID-19.Copyright © 2020 Société française de pharmacologie et de thérapeutique. Published by Elsevier Masson SAS. All rights reserved.

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