• Laura V Klotz, Michael Lindner, Martin E Eichhorn, Uwe Grützner, Ina Koch, Hauke Winter, Teresa Kauke, Thomas Duell, and Rudolf A Hatz.
• Center for Thoracic Surgery Munich, Ludwig-Maximilians-University of Munich/Asklepios Lung Clinic Gauting, Gauting, Germany.
• J Thorac Dis. 2019 May 1; 11 (5): 1963-1972.

BackgroundMalignant pleural mesothelioma (MPM) is an aggressive malignancy with few long-term survivors. Despite the dismal prognosis, hyperthermic intrathoracic chemoperfusion (HITHOC) was shown to improve survival in a selective group of patients. We analyzed the influence of HITHOC following pleurectomy and decortication on postoperative morbidity and overall survival for patients suffering from localized mesothelioma.MethodsFrom 2009 until 2013, 71 patients with localized pleural mesothelioma underwent pleurectomy and decortication followed by HITHOC with cisplatin and doxorubicin. We analyzed postoperative morbidity, age, overall survival and influence of macroscopic resection on survival.ResultsMedian patient age was 70 years (range, 65-73 years). Patients having the sarcomatoid subtype of mesothelioma showed a poor median survival of 9.2 months. In contrast, patients having the epithelioid subtype had a median survival of 17.9 months. Patients following macroscopic complete resection had a significantly better survival with 28.2 months compared to 13.1 months in patients with incomplete resection of the mesothelioma (P<0.0001). HITHOC was performed in all patients after tumor resection using cisplatin and doxorubicin.ConclusionsTaken together, HITHOC following pleurectomy and decortication is supposed to be a safe therapeutic option for selected patients with localized epithelial pleural mesothelioma.

2 keywords...

hide…