• Lun Li, Ye Gu, Tao Liu, Yupeng Bai, Lingbo Hou, Zhong Cheng, Liqun Hu, and Bo Gao.
• Department of Cardiology, Wuhan Puai Hospital, Huazhong University Of Science and Technology, Wuhan, China.
• Plos One. 2012 Jan 1; 7 (6): e38851.

ObjectiveThe aim of this study is to observe the chronic effects of diltiazem release capsules on patients with coronary slow flow (CSF) phenomenon.MethodsFrom 2004 to 2009, 80 consecutive patients with chest pain and normal coronary arteries evidenced by coronary angiography and CSF were included in this randomized, double-blind, placebo-controlled trial. CSF patterns were evaluated by the corrected TIMI frame count. Patients were randomly assigned at 1:1 ratio to diltiazem sustained-release capsules treatment group (Dil, 90 mg twice daily) or placebo control group. Holter, liver and kidney function, treadmill exercise test, coronary angiography and left ventricular angiography were measured at baseline and after 6 months. The incidence of cardiovascular events (re-admission or progress in coronary heart disease, myocardial infarction, malignant arrhythmia or cardiac death) was evaluated during the 6 months follow up.ResultsThirty-nine patients in control and 40 patients in Dil group completed the 6 months follow-up. There was no medication induced drug withdraw during follow up. Left ventricular ejection fraction was similar between the 2 groups at baseline and during follow up. Heart rate was significantly lower in Dil group than in control group and there was no symptomatic bradycardia and II and III degree atrioventricular conduction block in both groups. Significant improvement was observed in the onset of chest pain, treadmill exercise test and coronary blood flow in Dil group while these parameters remained unchanged in control group at the end of 6 months follow up. The incidence of cardiovascular events was similar between the two groups.ConclusionDiltiazem slow-release capsules improved coronary blood flow and alleviated angina in patients with CSF.Trial RegistrationChinese Clinical Trial Registry ChiCTR-TCC-11001864.

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