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- Charlotte Vanhomwegen, Olivier Taton, Nicolas Selvais, Olivier Vanhove, and Dimitri Leduc.
- CHU Erasme Hospital, Université Libre de Bruxelles, Route de Lennick 808, 1070, Brussels, Belgium. cvhomweg@gmail.com.
- BMC Pulm Med. 2021 Apr 19; 21 (1): 126.
BackgroundPlatypnea-orthodeoxia syndrome (POS) is a rare condition characterized by dyspnoea (platypnea) and arterial desaturation in the upright position resolved in the supine position (orthodeoxia). Intracardiac shunt, pulmonary ventilation-perfusion mismatch and others intrapulmonary abnormalities are involved.Case PresentationWe report a case of POS associated with two pathophysiological issues: one, cardiac POS caused by a patent foramen ovale (PFO) and second, pulmonary POS due to severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) interstitial pneumonia. POS has resolved after recovery of coronavirus disease 2019 (COVID-19) pneumonia.ConclusionsRight-to-left interatrial shunt and intrapulmonary shunt caused by SARS-CoV-2 pneumonia contributed to refractory hypoxemia and POS. Therefore, in case of COVID-19 patient with unexplained POS, the existence of PFO must be investigated.
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