• J. Thorac. Cardiovasc. Surg. · Nov 2012

    Editorial Review

    Aprotinin revisited.

    • Abe Deanda and Bruce D Spiess.
    • Department of Cardiothoracic Surgery, NYU-Langone Medical Center, New York, NY, USA. abe.deanda@nyumc.org
    • J. Thorac. Cardiovasc. Surg. 2012 Nov 1; 144 (5): 998-1002.

    AbstractIn 2008, we saw the withdrawal of aprotinin from the US markets after preliminary results from a large, randomized clinical trial in Canada. This drug, a potent antifibrinolytic, was used primarily in complex and/or redo cardiac surgery as an adjunct to decrease postoperative bleeding and complications. The Canadian study raised questions previously brought up in similar studies-does aprotinin increase the risk of mortality and renal failure after cardiac surgery? Recently, a re-review of the Canadian data noted flaws in the study, as well as in the interpretation of the results. The present review revisits the aprotinin controversy.Copyright © 2012 The American Association for Thoracic Surgery. Published by Mosby, Inc. All rights reserved.

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