• Neurology · Aug 2009

    Randomized Controlled Trial Comparative Study

    Migraine frequency and risk of cardiovascular disease in women.

    • Tobias Kurth, Markus Schürks, Giancarlo Logroscino, and Julie E Buring.
    • Division of Preventive Medicine, Brigham and Women's Hospital, Harvard Medical School, Boston, USA. tkurth@rics.bwh.harvard.edu
    • Neurology. 2009 Aug 25; 73 (8): 581-8.

    BackgroundMigraine has been associated with risk of cardiovascular disease (CVD). Data on the association between migraine frequency and CVD are sparse.MethodsProspective cohort study of 27,798 US women aged >or=45 years, who were free of CVD, and for whom we had information on lipids and migraine frequency. We categorized migraine frequency as < monthly, monthly, and >or= weekly. Incident CVD was confirmed after medical record review.ResultsOf the 3,568 women with active migraine at baseline, 75.3% reported a migraine frequency of < monthly, 19.7% monthly, and 5.0% >or= weekly. During 11.9 years of follow-up, 706 CVD events occurred. Compared with women without migraine, the multivariable-adjusted hazard ratios (HRs) (95% confidence intervals) among active migraineurs for CVD were 1.55 (1.22-1.97), 0.65 (0.31-1.38), and 1.93 (0.86-4.33) for an attack frequency of < monthly, monthly, and >or= weekly, respectively. The association between migraine frequency and CVD was only apparent among migraineurs with aura. Among those, the multivariable-adjusted HRs for women with a migraine frequency < monthly ranged from 1.81 (1.30-2.50) for coronary revascularizations to 2.43 (1.58-3.74) for myocardial infarction. For women with active migraine with aura and migraine frequencies of >or= weekly, we only found significant increased risk of ischemic stroke (HR = 4.25 [1.36-13.29]).ConclusionsIn our data, the association between migraine and cardiovascular disease varies by migraine frequency. Significant associations were only found among women with migraine with aura. Ischemic stroke was the only outcome associated with a high-attack frequency while a low-attack frequency was associated with any vascular event. Low number of outcome events should caution the interpretation.

      Pubmed     Full text   Copy Citation     Plaintext  

      Add institutional full text...

    Notes

     
    Knowledge, pearl, summary or comment to share?
    300 characters remaining
    help        
    You can also include formatting, links, images and footnotes in your notes
    • Simple formatting can be added to notes, such as *italics*, _underline_ or **bold**.
    • Superscript can be denoted by <sup>text</sup> and subscript <sub>text</sub>.
    • Numbered or bulleted lists can be created using either numbered lines 1. 2. 3., hyphens - or asterisks *.
    • Links can be included with: [my link to pubmed](http://pubmed.com)
    • Images can be included with: ![alt text](https://bestmedicaljournal.com/study_graph.jpg "Image Title Text")
    • For footnotes use [^1](This is a footnote.) inline.
    • Or use an inline reference [^1] to refer to a longer footnote elseweher in the document [^1]: This is a long footnote..

    hide…