• Krzysztof J Geras, Ritse M Mann, and Linda Moy.
• From the Center for Biomedical Imaging (K.J.G., L.M.), Center for Data Science (K.J.G.), Center for Advanced Imaging Innovation and Research (L.M.), and Laura and Isaac Perlmutter Cancer Center (L.M.), New York University School of Medicine, 160 E 34th St, 3rd Floor, New York, NY 10016; Department of Radiology and Nuclear Medicine, Radboud University Medical Centre, Nijmegen, the Netherlands (R.M.M.); and Department of Radiology, the Netherlands Cancer Institute-Antoni van Leeuwenhoek Hospital, Amsterdam, the Netherlands (R.M.M.).
• Radiology. 2019 Nov 1; 293 (2): 246-259.

AbstractAlthough computer-aided diagnosis (CAD) is widely used in mammography, conventional CAD programs that use prompts to indicate potential cancers on the mammograms have not led to an improvement in diagnostic accuracy. Because of the advances in machine learning, especially with use of deep (multilayered) convolutional neural networks, artificial intelligence has undergone a transformation that has improved the quality of the predictions of the models. Recently, such deep learning algorithms have been applied to mammography and digital breast tomosynthesis (DBT). In this review, the authors explain how deep learning works in the context of mammography and DBT and define the important technical challenges. Subsequently, they discuss the current status and future perspectives of artificial intelligence-based clinical applications for mammography, DBT, and radiomics. Available algorithms are advanced and approach the performance of radiologists-especially for cancer detection and risk prediction at mammography. However, clinical validation is largely lacking, and it is not clear how the power of deep learning should be used to optimize practice. Further development of deep learning models is necessary for DBT, and this requires collection of larger databases. It is expected that deep learning will eventually have an important role in DBT, including the generation of synthetic images.© RSNA, 2019.

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